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high throughput screening

SignalChem’s targets out-perform the competition.
All activity assays were performed in-house under the same experimental conditions.

    HTS TARGETS IN SCREEN
 
Target Categories:     All   |  Active Kinases  |  Active Phosphatases  |  Active Phosphodiesterases  |  Cellular Proteins  |  Active Histone Deacetylases

» View Full List  |  » Close

ABL1   ABL1   ABL2
ACK   AKT1   AKT2
AKT2   AKT3   ALK1
ALK2   ALK4   AMPK (A1/B1/G1)
AMPK (A1/B1/G2)   AMPK (A1/B1/G3)   AMPK (A1/B2/G1)
AMPK (A2/B1/G1)   AMPK (A2/B2/G2)   AMPK(A2B2G1)
AMPK(A2B2G3)   ASK1   AURORA A
AURORA A   AURORA B   AURORA C
AXL   BLK   BMX
BRAF   BRAF (V599E)   BRK
BTK   c-KIT   c-KIT(V654A)
c-MER   CAMK1   CAMK1β
CAMK1δ   CAMK1γ   CAMK1γ
CAMK2α   CAMK2β   CAMK2δ
CAMK2γ   CAMK4   CAMKK1
CAMKK2   CDC25B   CDC25C
CDK1/CyclinA1   CDK1/CyclinA2   CDK1/CyclinB1
CDK2/CyclinA1   CDK2/CyclinA2   CDK2/CyclinE1
CDK3/CyclinE1   CDK4/CyclinD1   CDK4/CyclinD3
CDK5/p25   CDK5/p29   CDK5/p35
CDK6/CyclinD1   CDK6/CyclinD3   CDK7/CyclinH/MNAT1
CDK8/CyclinC   CDK9/CyclinK   CHK1
CHK1   CHK2   CK2α1
CK2α2   CLK1   CLK2
CLK3   COT   CSK
CSK   DAPK1   DAPK2
DAPK3   DCAMKL2   DDR1  
DDR2   DMPK   DUSP22 (MKPX)
DYRK1α   DYRK3   EEF2K
EGFR   EIF2AK2   EIF2AK3
EPHA1   EPHA2   EPHA3
EPHA4   EPHA6   EPHB1
EPHB2   EPHB3   EPHB4
ERK1   ERK2   FAK
FER   FES   FGFR1 (FLT2)
FGFR1 (V561M)   FGFR2   FGFR3
FGFR4   FGR   FLT1
FLT3   FMS   FRK
FYN A   GCK   GRK2
GRK5   GRK6   GRK7
GSK3α   GSK3β   HCK
HDAC1     HDAC10     HDAC11  
HDAC2     HDAC3     HDAC5  
HDAC7     HDAC8     HDAC9  
HER2   HER4   HIPK1
HIPK3   HIPK4   IGF1R
InsR   IRAK2   IRAK4
IRR   ITK   JAK3
JNK1   JNK2   JNK3
KDR   KHS1   LCK
LIMK1   LKB1/MO25a/STRADa   LOK
LRRK2   LYN A   LYN B
MAPKAPK2   MAPKAPK2   MAPKAPK3
MAPKAPK5   MARK1   MARK2
MARK3   MARK4   MEK1
MEK1 (EE)   MEK2   MEK2
MEKK2   MEKK3   MET
MET   MINK1   MLCK
MLK3   MNK1   MNK2
MRCKα   MRCKβ   MSK1
MSSK1   MST1   MST3
MST4   MUSK   MYLK2
MYLK3   MYO3β   MYT1
NDR   NEK11   NEK2
NEK3   NEK6   NEK7
NEK9   NUAK2   p38α
p38β   p38δ   p38γ
p70S6K   p70S6Kb   PAK1/CDC42
PAK2   PAK3   PAK4
PAK6   PAK7   PASK
PDE10A   PDE11A   PDE1A
PDE1B     PDE1C   PDE2A
PDE3A   PDE3B   PDE4A
PDE4B   PDE4C   PDE4D
PDE5A   PDE6A     PDE6B
PDE7A   PDE7B     PDE8A
PDE9A   PDGFRα   PDGFRα
PDGFRβ   PDK1   PHKG2
PI3K (p110α(E545K)/p85α)   PI3K (p110α/p65α)   PI3K (p110β/p85α)
PI3K (p110α/p85α)   PI3K (p110δ/p85α)   PI3K (p120γ)
PI3K (Vps34/Vps15)   PIM1   PIM2
PKAcα   PKAcβ   PKAcγ
PKCα   PKCα   PKCβ I
PKCβ II   PKCδ   PKCε
PKCη   PKCγ   PKCι
PKCμ   PKCν   PKCθ
PKCζ   PKD2   PKN1
PKN2/PRK2   PLK1   PLK2
PLK4   PRKG1   PRKG2
PRKX   PTPN1 (PTP1B)   PTPN11 (SHP2)
PTPN12 (PTP-PEST)   PTPN13 (FAP-1)   PTPN2 (TC-PTP)
PTPN6 (SHP1)   PTPN7 (LC-PTP)   PTPRA (LRP)
PTPRC (CD45)   PTPRF (LAR)   PTPRS (PTPσ)
PYK2   QIK   RAF1
RAF1(EE)   RET   RIPK2
RIPK5   ROCK1   ROCK2
RON   ROR2   ROS1
RSK1   RSK2   RSK3
RSK4   SGK1   SGK2
SGK3   SIK   SIRT1  
SIRT2     SIRT3     SIRT5  
SIRT7     SLK   SOK1
SPHK1   SPHK2   SRC
SRC   SRPK1   SRPK2
STK3   STK33   SYK
TAK1-TAB1   TAOK1   TAOK2
TAOK3   TBK1   TEC
TESK1   TGFβR2   TIE 2
TLK2   TOPK   TRKA
TRKB   TRKC   TSSK1
TSSK2   TTK   TXK
TYK2   TYRO3   ULK1
ULK2   ULK3     WEE1
Yes1   ZAK   ZAP70
 

The range of targets being produced span across all major signaling pathways and incorporate members of the main protein kinase and protein phosphatase target families. All of the targets utilized in SignalChem’s compound profiling service are produced in-house and our rigorous quality control measures ensure the highest specific activity and purity of our targets.



profiling services

SignalChem employs the “Gold Standard” radiolabel-based kinase screening format as part of its profiling service as it provides several advantages over some of the newer technologies. In particular, the radiolabel format provides a direct measure of catalytic activity, has the highest signal-to-noise ratio and has minimal issues with compound interference.


The discovery team at SignalChem has over 30 years of combined experience in the areas of signal transduction, enzyme kinetics and high throughput screening. We are committed to delivering the highest quality products and services and have been highly successful in establishing strong partnerships with several large life science, biotech and pharmaceutical companies.


profiling services
kinase profiling

SignalChem understands the importance of discovery timelines and works to provide the profiling results within a two-week time period. A typical report includes a detailed summary of the results, graphical and numerical representation of the findings along with the original data.

Recent References:
1. Ong, CJ. et al: Small molecule agonists of SHIP1 inhibit the phosphoinositide 3-kinase pathway in hematopoietic cells. Blood 2007 May 14; Epub.

 


    Who We Are
 

SignalChem is a life science reagent company focused on the research, development and production of innovative cell signaling products to advance basic research and drug discovery efforts, with specific emphasis on the production of highly purified biologically active human recombinant proteins

 


    NEW PRODUCTS
  SIRT1 Protein   FKBP1A Protein  
  EIF2AK3, Active   PDE10A, Active  
  PI3K (p110α/p85α), Active   HDAC11, Active  
  HDAC10, Active   PAK4, Active  
  PAK4, Active   CAMK1γ, Active  
  HDAC8, Active   IRAK2, Active  
  HDAC7, Active   HDAC9, Active  
  HDAC5, Active   HDAC3, Active  
  HDAC2, Active   PRKG1, Active  
  PDE6A, Active   HDAC1, Active  
    POPULAR PRODUCTS
  AKT1, Active   AKT3, Active  
  PI3K (p110α/p85α), Active   p53 Protein  
  SMAD3 Protein   GSK3β, Active  
  AKT2, Active   AMPK (A1/B1/G1), Active  
  Akt(PKB) Substrate   SMAD2 Protein  
  PDK1, Active   AKT2, Active  
  AKT2, Unactive   PI3K (p110β/p85α), Active  
  p53 Protein   AKT1, Unactive  
  p38α, Active   GSK3α, Active  
  GSK3β, Active   MAPKAPK2, Active  




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